In this article we explore Covid-19 riskscapes across the African Great Lakes region. Drawing on fieldwork across Uganda and Malawi, our analysis centers around how two mobile, trans-border figures – truck drivers and migrant traders – came to be understood as shifting, yet central loci of perceived viral risk. We argue that political decision-making processes, with specific reference to the influence of Covid-19 testing regimes and reported disease metrics, aggravated antecedent geographies of blame targeted at mobile “others”. We find that using grounded riskscapes to examine localised renditions of risk reveals otherwise neglected forms of discriminatory discourse and practice.