This paper reports a mixed methods study to assess the preparedness of Community Health Workers (CHWs) in supporting health system response in prevention and management of COVID-19 in Kenya, Senegal, and Uganda. Interviews were conducted with policy actors, health care workers, CHWs and community members. Findings underscore the important role CHWs play in supporting HS during crisis like COVID-19 to mitigate disruptions and stabilize the system for effective response. The CHWs can improve resilience of social and HS during unplanned disruptions for optimal functioning and attainment of universal health care. Policy makers should develop structured mechanisms for engaging CHWs while committing resources to address challenges that affect seamless synergy between health and CHWs Systems.